1/12/2024 0 Comments Blue indigo snake venom cancerUpregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+ -mediated p38 MAPK activation. Arachidonic acid lipoxygenation may mediate interleukin-1 stimulation of nerve growth factor secretion in astroglial cultures. Elevated and secreted phospholipase A2 activities as new potential therapeutic targets in human epithelial ovarian cancer. 2009 23(1):49–59.Ĭai Q, Zhao Z, Antalis C, Yan L, Del Priore G, Hamed AH, Stehman FB, Schilder JM, Xu Y. Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site. 2004 365(3):218–22.Īrita H, Hanasaki K, Nakano T, Oka S, Teraoka H, Matsumoto K. Nerve growth factor-induced up-regulation of cytosolic phospholipase A2alpha level in rat PC12 cells. KeywordsĪkiyama N, Hatori Y, Takashiro Y, Hirabayashi T, Saito T, Murayama T. svPLA2 application for the study of antiproliferative effects may boost the discovery of a new biochemical mechanism for inhibition of tumor cell growth. As carcinogenesis and hypercoagulation promote each other, svPLA2s possessing both antiproliferative and anticoagulant properties would be promising candidates in cancer research. Antiproliferative svPLA2s may realize their effects also through interaction with growth factor receptors and integrins. The comparison uncovered the partial overlap of two pathways. As nerve growth factor (NGF), another snake venom component, also induces differentiation in neuronal cell lines, respective biochemical pathways are compared basing mostly on the data obtained for endogenous mammalian PLA2s and NGFs. While the products of phospholipid hydrolysis by PLA2s and their metabolites influence several cellular processes including proliferation, svPLA2 antiproliferative effects may be accomplished by other mechanisms in which cell surface membrane proteins (e.g., PLA2 receptors) and intracellular signal transduction pathways take part. The antiproliferative effect shows no direct correlation with svPLA2 cytotoxicity and enzymatic activity. This chapter is the first attempt to systemize the data about the biochemical mechanism of the antiproliferative effect of svPLA2s. As PLA2s are the most abundant proteins in snake venoms, their numerous biological effects including antiproliferative ones are well studied. This effect of svPLA2s was discovered almost two decades ago however, so far its biochemical basis is not completely clear. Mammalian PLA2s mostly enhance tumor cell proliferation, while snake venom PLA2s (svPLA2s) are capable to inhibit it. Secretory phospholipases A2 (PLA2s) are ubiquitous enzymes taking part in different biological pathways including cell growth and differentiation.
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